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Franklin died at her Los Angeles home, and is survived by her mother, Claire Franklin, and stepchildren Jed Minoff and Julie Minoff, said the paper.
On the long-running CBS series, which was developed by Norman Lear and on the air from 1975-1984, Franklin starred as divorced mom Ann Romano, alongside Mackenzie Phillips and Valerie Bertinelli, who played her teenage daughters.
Franklin and Bertinelli reunited on the small screen in 2011 when the Franklin played the mother of Bertinelli's character's boyfriend on Hot in Cleveland.
When Franklin's disease was first revealed, Phillips Tweeted, "Sending out love and sweet prayers to my 'mom.' The incomparable Bonnie Franklin."
A California native, Franklin was born in the beach city of Santa Monica but moved to Beverly Hills as a teen. Her father was a Russian-born investment banker, and her mother was born in Romania – and they remained her most ardent fans. She attended Smith College in Massachusetts and then transferred to UCLA.
Acting since childhood, Franklin first appeared on TV at the age of 3 (reciting Shakespeare) and in movies – including Alfred Hitchcock's The Wrong Man, starring Henry Fonda. In 1970 she sang the title song in the Tony-winning Lauren Bacall Broadway musical Applause. Franklin played a sunny chorus gypsy, and stopped the show twice.
From 1967 to 1970 she was married to the playwright Ronald Sossi, and then from 1980 until his death in 2009, to producer Marvin Minoff. Speaking to The New York Times about their marriage in 1980, Franklin said that she had promised Minoff that their years together would be many things, "but I promised him they weren't going to be boring."
Bonnie Franklin Dies at 69
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Bonnie Franklin Dies at 69
