Japan and Philippines to Bolster Maritime Cooperation





TOKYO — In a telling sign of how China’s rise has helped turn former wartime foes into allies, Japan and the Philippines agreed on Thursday to cooperate more closely on maritime security.




During talks in Manila, the foreign ministers of Japan and the Philippines proclaimed their nations to be strategic partners that would collaborate more in resolving their separate territorial disputes with China, news reports said. They also expressed “mutual concern” over increasingly assertive claims by China that have embroiled both nations, according to Kyodo News.


Japan is in a tense showdown over islands in the East China Sea, while the Philippines has wrangled with China over control of islands and fishing grounds in the South China Sea. The two nations agreed to exchange information and discuss each other’s strategies for responding to China, the ministers were quoted as saying. The Philippine minister, Albert del Rosario, said the discussion included a request by his country for 10 new patrol ships from Japan to strengthen the Filipino coast guard.


His Japanese counterpart, Fumio Kishida, was appointed last month by Japan’s new conservative prime minister, Shinzo Abe. The decision to have Mr. Kishida visit the Philippines for his first trip was seen as a symbolic gesture by Mr. Abe, who has vowed to strengthen security ties with other democracies in the region in an effort to offset China’s growing military and political clout.


Mr. Abe has also said he wants to work more closely with the United States and Australia to help bolster the capacity of less-developed nations like the Philippines to stand up to China. While long-pacifist Japan has restricted its aid to mostly nonmilitary purposes, like building up coast guards, its leaders have recently begun loosening some of the self-imposed restrictions. Japan is now in talks about providing training to submarine crews from Vietnam, and last year it gave its first limited military aid to East Timor and Cambodia.


Japan has long supplied development aid in the region, but it has operated carefully to avoid stirring bitter memories of its militarism during World War II, when its forces swept across much of Southeast Asia, including the Philippines, then an American colony. However, in recent years Japan’s military has slowly raised its profile by joining regional training exercises and holding its first bilateral military maneuvers with Australia and India.


The building of regional military ties represents a significant strategic departure for the country, which after World War II relied for its defense on the United States and the roughly 50,000 military personnel it bases in Japan. For its part, China has pointed to the moves as proof of a resurgent militarism in Japan, which it says is swinging to the right.


News reports said Mr. del Rosario, the Philippine minister, called China’s territorial claims in the South China Sea a threat to regional stability.


“We also need to be able to address the possibility that the freedom of navigation would be adversely affected,” he was quoted as saying by The Associated Press.


The Japanese foreign minister agreed.


“As the strategic environment is changing, it is necessary for us as foreign ministers to share recognition of the situation,” Mr. Kishida said after the talks, according to Kyodo News. Kyodo said that Mr. Kishida also offered development loans to help build a light-rail system and a new airport.


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Can Social Media Help You Lose Weight?






At the start of the New Year, when weight loss is often a priority, building a support team to help keep us on track can be extremely helpful. This might typically consist of family members, friends, co-workers, or perhaps even a nutritionist or registered dietitian. But today, support can also be found online. Plenty of Web sites focus on losing weight, and include communities that provide support and encouragement. Since many of us spend a lot of time on social media sites–maybe too much if you ask my husband!–why not use these platforms as another tool for support? In fact, one study suggests employees participating in a workplace wellness program who also joined the company’s Facebook page, run by a registered dietitian, stayed with the program longer than those who didn’t.


[See Already Struggling With Your New Year's Resolution?]






Could it actually make sense that gluing ourselves to our mobile device or computer could help us shed pounds? It sounds like quite the oxymoron, since increased screen time doesn’t usually equate to weight loss. But here’s how to make social media sites work for you:


Facebook


Facebook is a place where you can share what’s going on in your life with friends, but you may not feel comfortable announcing what you weigh or that you’re trying to lose weight. On the other hand, you may enjoy posting fitness milestones, such as training for and completing your first marathon, or a bike ride for your favorite charity. Sharing your fitness goals with the Facebook universe may be helpful, because the more people who know about it, the more likely you are to stay committed.


[See Small Steps, Big Change: How to Lose 50 Pounds Without Really Trying]


Rather than simply connecting with friends on the site, you can also connect with health and fitness professionals, such as registered dietitians, or pages for diet books, like mine, The Small Change Diet. You can also “like” the pages of health and fitness magazines and your favorite brands. The folks who run these pages may post articles that provide you with helpful weight-loss tips, and many organize regular Facebook chats, allowing you to ask an expert your questions. The more that healthy information is “in your face,” the more likely you are to stick to it.


Most importantly, you may discover a weight-loss community on Facebook, where like-minded individuals share their weight losses (or gains) and offer support. Daily accountability could be just what you need, and knowing others are rooting for you can make a world of difference. If you can’t find a Facebook community you like, start your own.


Twitter


So many of my patients don’t have Twitter accounts, because they think they have nothing clever or witty to say. My advice to them is always the same: You don’t have to “say” anything; you can just follow, at least at the beginning. Registered dietitians (I’m @kerigans) have great tips and, if they’re like me, are more than happy to answer questions via Twitter. I’ve had followers tweet a picture of their dinner and ask what my dietitian colleagues and I thought of it–priceless information for free.


[See Best Plant-Based Diets]


Just as you do on Facebook, follow fitness professionals, health magazines, and other sources that provide weight-loss motivation. Once you feel comfortable, you may decide to join in the conversation, since that’s what social media is all about. Perfect example of how it can benefit you: One morning, I tweeted that I felt more like staying in my pajamas than going to yoga. Some of my followers chimed in that they were feeling the same way, BUT stressed that we should all still exercise. And so we all did. And trust me, none of us regretted going–rather, we were thankful for each other.


[See Are Mobile Health Apps Helpful?]


Seek out people on Twitter and Facebook who you find inspirational, and hopefully a little of what they do will rub off on you. Since nothing is etched in stone, you can unfollow, unlike, or unfriend them if they aren’t helping you. And please keep in mind that while social media can be another tool in your pursuit of weight loss, it’s not the end all. Healthy eating, fitness, and plenty of sleep actually need to happen away from a screen.


Hungry for more? Write to [email protected] with your questions, concerns, and feedback


Keri Gans, MS, RD, CDN, is a registered dietitian, media personality, spokesperson, and author of The Small Change Diet. Gans’s expert nutrition advice has been featured in Glamour, Fitness, Health, Self and Shape, and on national television and radio, including The Dr. Oz Show, Good Morning America, ABC News, Primetime, and Sirius/XM Dr. Radio.


Social Media News Headlines – Yahoo! News





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Dennis Tyler Finds Homes for More Than 7,000 Retired Greyhounds






Heroes Among Us










01/10/2013 at 02:05 PM EST







Dennis Tyler and his greyhounds


Jeffery Salter


Dennis Tyler never expected to fall in love.

But after he took in a former racing greyhound named Clara Voyant in 1991, Tyler soon discovered that he'd found a constant companion in the affectionate light-brown dog, who strode beside him on daily walks and nestled against him while watching TV.

"She was a very special dog," recalls the Melbourne, Fla.-based father of two grown children. "She blended right into the family."

So when Tyler, 66, learned that many greyhounds, some injured while racing, faced the risk of being euthanized, he couldn't look the other way.

"These dogs can be the most wonderful pets," he says. "I needed to do something."

Since then the retired mechanic and his wife, Claire, 66, have found homes for more than 7,400 greyhounds through his nonprofit, Florida Greyhounds. Using donations, Tyler provides medical care for the dogs, personally matches them to a compatible family and drives them from his home state of Florida – which has the largest number of greyhound racetracks in the U.S. – to their new homes along the East Coast.

While the group briefly suspended operations last year due to new costs at track kennels in the area, Tyler says they'll be back up running later this month. His group has also started a fledgling foster dog program.

Lorie Stewart, of Satellite Beach, Fla., is one of the thousands of people who have benefitted from Tyler's efforts.

"I just adore my dogs," says Stewart, who's adopted five greyhounds through Florida Greyhounds. "They call them potato chip dogs because they're so addictive; you can't have just one!"

More Heroes Among Us:

• Hero Lawyer Gives His House to a Homeless Family for a Year

• Nine-Year-Old Cancer Victim's Happy Spirit Kept Alive Through Strangers' Donations

Know a hero? Send suggestions to heroesamongus@peoplemag.com. For more inspiring stories, read the latest issue of PEOPLE magazine

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China's one-child law: Less competitive adults?


BEIJING (AP) — They're called "little emperors" — the children born in China under a law that generally limits urban families to having just one child.


They grow up as the sole focus of doting parents. How does this affect them? What does it mean to Chinese society if generations of kids are raised this way?


Concerns about the "only child" practice in China have been expressed before. Now researchers present new evidence that these children are less trusting, less competitive, more pessimistic, less conscientious and more risk-averse than people born before the policy was implemented.


The study's authors say the one-child policy has significant ramifications for Chinese society, leading to less risk-taking in the labor market and possibly fewer entrepreneurs.


"Trust is really important, not just social interactions but in terms of negotiations in business, working with colleagues in business, negotiating between firms," said one of the authors, Lisa Cameron. "If we have lower levels of trust, that could make these kinds of negotiations and interactions more difficult."


China introduced its family planning policy in 1979 to curb a surging population. It limits most urban couples to one child.


The new work by Cameron of Monash University in Australia and co-authors is published online Friday in the journal Science. The researchers said the results don't necessarily apply to children born outside of the situation they studied: modern-day, urban China.


They recruited 421 Beijing men and women who were born within an eight-year period that included dates just before and just after the policy took effect in 1979. About 27 percent of the participants born in 1975 were the only child in their families, rising to 82 percent of those born in 1980 and 91 percent of those born in 1983. Researchers said the sample was better educated than the general population of Beijing but otherwise similar.


They administered tests to measure their altruism, trust, trustworthiness, risk attitudes and competitiveness, and gave them personality surveys. Cameron said the participants' ages and views on ideological changes in China didn't appear to affect the results.


The findings — including indications that those in the study were more sensitive and nervous — are no surprise, said Zou Hong of the School of Psychology at Beijing Normal University, who was not involved in the research.


"Only children in Chinese families are loved and given almost everything by their families and they can get resources at home without competition," she said. "Once they enter society, they are no different from other people. Having been overly protected, they feel a sense of loss and show less competitiveness."


Zou said parents of an only child tend to become overly nervous, when they are ill, for example, and "that feeling will be passed on to the children and make them become more sensitive and nervous."


The Chinese government credits the one-child policy with preventing hundreds of millions of births and helping lift countless families out of poverty. But the strict limits have led to forced abortions and sterilizations, even though such measures are illegal. Couples who flout the rules face hefty fines, seizure of their property and loss of their jobs.


Last year, a government think tank urged China's leaders to start phasing out the policy and allow two children for every family by 2015, saying the country had paid a "huge political and social cost." It said the policy had resulted in social conflict, high administrative costs and led indirectly to a long-term gender imbalance because of illegal abortions of female fetuses and the infanticide of baby girls by parents who cling to a traditional preference for a son.


The researchers in Australia noted that children born long after 1979 will have grown up with very limited extended family and in a society dominated by those born into one-child families. So the psychological effects of the one-child policy "would, if anything, be magnified," they wrote.


Toni Falbo, a professor of educational psychology at the University of Texas in Austin who studies these children, was puzzled that the study's findings showed poor performance so consistently in virtually all measures. She said she would have expected a more mixed picture, and she hopes follow-up research is done.


In any case, there's no reason to think that the results would be similar for children in the United States, she said. In China the only child grows up with different expectations, Falbo said, with Chinese authorities emphasizing that "these kids have to be the best possible. Most Americans want their kid to be happy; they're not aiming for a world-class child of some sort."


Careful studies done elsewhere that look for certain qualities in the only child find that "on average, they're pretty much like everybody else," she said.


__


Science writer Malcolm Ritter in New York and AP researcher Yu Bing in Beijing contributed to this report.


___


Online:


Journal Science: http://www.sciencemag.org


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Wall Street climbs on China data; S&P nears resistance

NEW YORK (Reuters) - Stocks climbed on Thursday on optimism about global growth spurred by stronger-than-expected exports in China, the world's second-biggest economy, and the S&P 500 hovered around a five-year high.


Financial and energy stocks were the day's top gainers in afternoon trading. The financial sector index <.gspf> rose 1 percent and the energy sector <.gspe> was up 0.7 percent.


Financials benefited from events this week that added clarity to mortgage rules and banks' potential exposure to the housing market.


The government's consumer finance watchdog announced mortgage rules on Thursday that will force banks to use new criteria to determine whether a borrower can repay a home loan.


Earlier this week, several big mortgage lenders reached a deal with regulators to end a review of foreclosures mandated by the government.


Bank of America gained 2.6 percent to $11.73, while Morgan Stanley was up 3.2 percent at $20.24, one day after sources said the bank plans to cut jobs.


"It's a resolution. It's not hanging over their heads," said Kurt Brunner, portfolio manager at Swarthmore Group in Philadelphia, Pennsylvania.


Data showed China's export growth rebounded sharply to a seven-month high in December, a strong finish to the year after seven straight quarters of slowdown.


"In and of itself it is being interpreted positively that they've stopped the downturn (in growth)," said Brunner. "If they continue to produce good growth, that's going to be supportive of our global manufacturers."


The benchmark Standard & Poor's 500 index hovered near a five-year closing peak of 1,466.47. On Friday, the index had closed at its highest since December 2007.


"The market is technically right at the level of resistance, near 1,465-1,467," said Randy Frederick, managing director of active trading and derivatives at Charles Schwab.


"A solid breakthrough above the level would be the start of a next leg higher, but it looks like it is going to be difficult to break above that level for now," Frederick said, citing concerns about the corporate earnings season and impending negotiations over the U.S. debt ceiling.


The Dow Jones industrial average <.dji> gained 40.53 points, or 0.30 percent, to 13,431.04. The Standard & Poor's 500 Index <.spx> rose 5.41 points, or 0.37 percent, to 1,466.43. The Nasdaq Composite Index <.ixic> edged up 0.42 points, or 0.01 percent, at 3,106.23.


Thursday's session had earlier included a dip that traders said was triggered by a trade in the options market that prompted a large amount of S&P futures to hit the market at the same time. That sent the S&P 500 index down rapidly but those losses were recouped by late afternoon.


Shares of upscale jeweler Tiffany dropped 5.1 percent to $60.02 after it said sales were flat during the holidays.


Herbalife Ltd stepped up its defense against activist investor Bill Ackman, stressing it was a legitimate company with a mission to improve nutrition and help public health. The stock was down 3 percent at $38.75.


(Editing by Nick Zieminski)



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Iranian Captives Freed in Major Prisoner Exchange in Syria





ISTANBUL — More than 2,000 prisoners incarcerated by the Syrian authorities were being released on Wednesday in return for 48 Iranians freed by rebels after five months in captivity in what appeared to be the biggest prisoner swap since the uprising against President Bashar al-Assad began almost two years ago.




The exchange, brokered by Turkey and Qatar, came days after Mr. Assad warned on Sunday that he would not abandon the fight against armed adversaries pressing on the approaches to the Syrian capital, Damascus, and brushed aside calls for him to quit.


Word of the exchange dominated news in Iran, the Syrian government’s only Middle East ally, leading the Web site of the official Islamic Republic News Agency. Iran state television showed a brief clip of the released hostages at the Sheraton Hotel in Damascus, grinning, flashing victory signs and holding flowers. In an interview on Iran state TV, the Foreign Ministry spokesman, Ramin Mehmanparast, thanked those involved in the swap for the hostages and expressed happiness that “we managed to get them released.”


Precise details of the exchange, including when the 48 Iranians would be repatriated, remained unclear. Mr. Mehmanparast also said two Iranian engineers who had been abducted earlier in Syria remained captive. But Prime Minister Recep Tayyip Erdogan of Turkey, a regional power broker allied to the Western and Arab nations seeking Mr. Assad’s departure, said he hoped the exchange on Wednesday would lead to freedom for more prisoners in Syria.


“We wish many other innocent people, and people in need, to be released from Syrian jails without delay,” Mr. Erdogan said in a televised news conference in Niamey, Nigeria, where he arrived on an official visit.


“This process needs to be appreciated. We are not in a position to say anything more than, ‘May this produce some good.’ ”


The exchange emerged from months of behind-the-scenes negotiations involving a Turkish charitable foundation, the Humanitarian Relief Foundation, an Islamist-leaning aid organization based in Istanbul and widely known as I.H.H.


The aid group had set up an operation center in Damascus to unite 2,130 prisoners, including 73 women, at one base while another aid team remained in Douma, near the Syrian capital, to oversee the return of the 48 Iranians.


“Captivity is a hard thing,” said Bulent Yildirim, the foundation’s director, who coordinated the exchange in Damascus.


“I saw young women crying, many people lost a lot of weight, and there were also many sick people.”


The Syrian opposition has claimed that the Iranians are members of Iran’s Islamic Revolutionary Guards Corps, but Tehran has denied the assertion, saying the captives are Shiite civilian pilgrims. The Iranians were seized in August while traveling on a bus from Damascus International Airport to a Shiite shrine on the outskirts of the capital, Iran’s Press TV said.


Opposition fighters had threatened to kill the Iranians unless Mr. Assad’s forces halted military operations. But since then the fighting around Damascus has intensified.


Iran is Mr. Assad’s main ally in a region where most Arab states and neighboring Turkey have turned against him. The Iranian captives offered the rebels holding them a source of powerful pressure on the Syrian leader to release opposition prisoners in return.


“We expect the swap to be completed in the next hour,” Huseyin Oruc, a member of the aid group’s executive board said in a telephone interview around midday. He said the captives released by the Syrian authorities included four Turks and a Palestinian.


By midafternoon it was not clear whether the 2,130 prisoners had been freed.


“It is the first time that the ‘humanitarian diplomacy’ we initiated succeeded in releasing such a large group of people at once,” Mr. Oruc said. “There are many more held captive and our efforts to free them will continue without delay.”


The Turkish aid group gained international attention in 2010 for organizing a flotilla of boats heading to Gaza, ostensibly with relief supplies, that prompted a deadly Israeli commando raid in which eight Turks and an American of Turkish descent died. At the time of the raid, the group was reported to have extensive connections with Turkey’s political elite. The episode began an unraveling of Turkey’s once close ties with Israel.


In recent months, the organization has also been part of negotiations to free smaller numbers of prisoners, including two Turkish journalists held in Syria, Reuters reported. It has been active since the early 1990s in charitable works in the Middle East and Africa, focusing most recently on Gaza.


Since the start of the uprising against Mr. Assad, the organization has also cast itself as a leading private charitable organization in Syria, delivering food and other basic supplies and pursuing what it calls “humanitarian diplomacy” to help free captive civilians.


While the numbers involved in Wednesday’s exchange seemed dramatic, some rebel commanders said more modest prisoner exchanges had become a feature of the conflict.


The leader of a rebel fighting group in the central city of Hama, reached via Skype, said pro-government militia members had captured his uncle and two other relatives in a village in the northern Idlib province more than a month ago.


 “The  only  way to release them is capturing  hostages,” the commander said, adding that negotiations were under way to win the release of his relatives in return for 12 captives held by the rebels. Two months ago, the commander said, nine members of the pro-government militia, known as shabiha, were  exchanged for five captured rebels. Syria’s uprising began in March 2011 with peaceful demonstrations, but a harsh suppression broadened into civil war with an estimated 60,000 people killed, according to United Nations estimates.


Sebnem Arsu reported from Istanbul and Alan Cowell from London. Hwaida Saad contributed reporting from Beirut, Lebanon, and Thomas Erdbrink from Tehran.



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Nintendo president describes Wii U sales as ‘not bad’






Nintendo’s (NTDOY) new Wii U gaming console came out of the gate strong and saw first-week sales reach 400,000 units in the U.S., however sales have since stalled and the system has been labeled a flop by some. While consumer interest in the company’s new console has slowed right out of the gate, Nintendo’s president recently said that he isn’t worried even though sales aren’t where he hoped they would be.


[More from BGR: Smooth sailing is over for Apple]






“At the end of the Christmas season, it wasn’t as though stores in the U.S. had no Wii U left in stock, as it was when Wii was first sold in that popular boom,” Nintendo President Satoru Iwata said in an interview with Reuters. “But sales are not bad, and I feel it’s selling steadily.”


[More from BGR: New ‘higher-end’ iPhone reportedly launching by June, low-end model could be coming as well]


The executive declined to give specific details on sales or forecasts, although he did say that Nintendo plans to focus on developing attractive software for its 3DS handheld to appeal to new users, and will seek new ways to increase Wii U sales in a changing market.


Nintendo previously announced that it hopes to sell 5.5 million Wii U devices by the end of March and more than 24 million Wii U games in the same timeframe.


This article was originally published by BGR


Gaming News Headlines – Yahoo! News





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Mark Wahlberg Does Weather and Traffic Reports in Philadelphia















01/09/2013 at 02:30 PM EST



The weather is nice and mild in Philadelphia but things got pretty rowdy inside the weather room at local news station Fox 29's Good Day Philadelphia on Wednesday.

Mark Wahlberg and his Broken City director, Allen Hughes, took over the forecasting duties for weather anchor Sue Serio. (Watch his full report below.)

"This is perfect golf weather ... by the way," Wahlberg noted of a high of 54 degrees in the City of Brotherly Love.

Once the seven-day forecast was done, Wahlberg and Hughes lightened traffic reporter Kacie McDonnell's load and let Philadelphians know where they would find trouble on their morning commute.

"Look at this congestion here," Wahlberg said. "We're expecting 40- to 45-minute delays if you're coming east bound on the 676 here. You're going to have some serious problems. Why don't you stop and get yourself a hoagie?"

Broken City, which also stars Russell Crowe, opens Jan. 18.

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Wall Street up after Alcoa earnings news

NEW YORK (Reuters) - Stocks rose on Wednesday as Alcoa's better-than-expected revenue and a positive outlook boosted investor confidence ahead of an earnings season expected to show lackluster results.


The session's rise was the first of the week after the market retreated from the S&P 500's highest point in five years, hit last Friday. Worries about a weak earnings season kept the markets down earlier in the week.


Shares of Alcoa Inc were trading flat after early gains, following the company's earnings release after the bell on Tuesday. The largest U.S. aluminum producer said it expects global demand for aluminum to grow in 2013.


Traders have been cautious as the current quarter was shaping up like the previous one, with companies lowering expectations in recent weeks, said James Dailey, portfolio manager of TEAM Asset Strategy Fund in Harrisburg, Pennsylvania.


"So the big question and focus is on revenue, and Alcoa had better-than-expected revenue," which calmed the market a little, Dailey said.


Overall, corporate profits were expected to beat the previous quarter's meager 0.1 percent rise. Both earnings and revenues in the fourth quarter were expected to grow by 1.9 percent, according to Thomson Reuters data.


The lowered expectations also leave room for companies to surprise investors even if their results are not particularly strong, analysts said.


The Dow Jones industrial average <.dji> gained 59.47 points, or 0.45 percent, at 13,388.32. The Standard & Poor's 500 Index <.spx> rose 3.86 points, or 0.26 percent, at 1,461.01. The Nasdaq Composite Index <.ixic> was up 14.93 points, or 0.48 percent, at 3,106.74.


Clearwire Corp shares jumped 7.7 percent to $3.15 after Dish Network bid $2.28 billion for the company, trumping a previous Sprint offer and setting the stage for a takeover battle for the wireless service provider that owns crucial mobile spectrum.


Herbalife Ltd stock rose 4 percent to $39.89 following news that hedge fund manager Dan Loeb took a stake of more than 8 percent in the nutritional supplements seller, according to a regulatory filing. Prominent short-seller Bill Ackman had previously accused the company of being a "pyramid scheme," which Herbalife has vehemently denied.


Facebook Inc shares rose above $30 per share for the first time since July 2012, trading up 4.7 percent at $30.43. Facebook, which has been tight-lipped about its plans after its botched IPO in May, invited the media to its headquarters next week.


Apollo Group Inc slid after heavier losses early on, a day after it reported lower student sign-ups for the third straight quarter and cut its operating profit outlook for 2013. Apollo's shares were last off 6.6 percent at $19.55.


(Reporting by Gabriel Debenedetti; additional reporting by Angela Moon; Editing by Nick Zieminski)



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Retooling Pap test to spot more kinds of cancer


WASHINGTON (AP) — For years, doctors have lamented that there's no Pap test for deadly ovarian cancer. Wednesday, scientists reported a tantalizing hint that one day, there might be.


Researchers are trying to retool the Pap, a test for cervical cancer that millions of women get, so that it could spot early signs of other gynecologic cancers, too.


How? It turns out that cells can flake off of tumors in the ovaries or the lining of the uterus, and float down to rest in the cervix, where Pap tests are performed. These cells are too rare to recognize under the microscope. But researchers from Johns Hopkins University used some sophisticated DNA testing on the Pap samples to uncover the evidence — gene mutations that show cancer is present.


In a pilot study, they analyzed Pap smears from 46 women who already were diagnosed with either ovarian or endometrial cancer. The new technique found all the endometrial cancers and 41 percent of the ovarian tumors, the team reported Wednesday in the journal Science Translational Medicine.


This is very early-stage research, and women shouldn't expect any change in their routine Paps. It will take years of additional testing to prove if the so-called PapGene technique really could work as a screening tool, used to spot cancer in women who thought they were healthy.


"Now the hard work begins," said Hopkins oncologist Dr. Luis Diaz, whose team is collecting hundreds of additional Pap samples for more study and is exploring ways to enhance the detection of ovarian cancer.


But if it ultimately pans out, "the neat part about this is, the patient won't feel anything different," and the Pap wouldn't be performed differently, Diaz added. The extra work would come in a lab.


The gene-based technique marks a new approach toward cancer screening, and specialists are watching closely.


"This is very encouraging, and it shows great potential," said American Cancer Society genetics expert Michael Melner.


"We are a long way from being able to see any impact on our patients," cautioned Dr. Shannon Westin of the University of Texas MD Anderson Cancer Center. She reviewed the research in an accompanying editorial, and said the ovarian cancer detection would need improvement if the test is to work.


But she noted that ovarian cancer has poor survival rates because it's rarely caught early. "If this screening test could identify ovarian cancer at an early stage, there would be a profound impact on patient outcomes and mortality," Westin said.


More than 22,000 U.S. women are diagnosed with ovarian cancer each year, and more than 15,000 die. Symptoms such as pain and bloating seldom are obvious until the cancer is more advanced, and numerous attempts at screening tests have failed.


Endometrial cancer affects about 47,000 women a year, and kills about 8,000. There is no screening test for it either, but most women are diagnosed early because of postmenopausal bleeding.


The Hopkins research piggybacks on one of the most successful cancer screening tools, the Pap, and a newer technology used along with it. With a standard Pap, a little brush scrapes off cells from the cervix, which are stored in a vial to examine for signs of cervical cancer. Today, many women's Paps undergo an additional DNA-based test to see if they harbor the HPV virus, which can spur cervical cancer.


So the Hopkins team, funded largely by cancer advocacy groups, decided to look for DNA evidence of other gynecologic tumors. It developed a method to rapidly screen the Pap samples for those mutations using standard genetics equipment that Diaz said wouldn't add much to the cost of a Pap-plus-HPV test. He said the technique could detect both early-stage and more advanced tumors. Importantly, tests of Paps from 14 healthy women turned up no false alarms.


The endometrial cancers may have been easier to find because cells from those tumors don't have as far to travel as ovarian cancer cells, Diaz said. Researchers will study whether inserting the Pap brush deeper, testing during different times of the menstrual cycle, or other factors might improve detection of ovarian cancer.


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